Endocrine Abstracts

Physical examination in thyroid diseases, should it be relied on?M Sadri, C Y Yiangou, A. DhandaDepartment of thyroid surgery Queen Alexandra Hospital, PortsmouthObjective: Assessment of the accuracy of physical examination performed by thyroid surgery team doctors at thyroid clinic.Method: Random review of 120 new referrals to thyroid clinic, with review of clinical findings on physica...

Does Iodide Modulate The Biological Outcome of Activating Thyrotropin Receptor Mutations?Dr. F. Al-Khafaji and Dr. M. LudgateHyperthyroidism is caused by pathogenic activation of the thyrotropin receptor (TSHR) either by the thyroid stimulating antibodies of Graves' disease (GD) or activating TSHR mutations. These produce nodular goitre or familial hyperthyroidism. The pathogenic mechanism predominating varies according to the iodide intake, with nodular goitre account...

Women’s bone metabolism is regulated by estrogens and interleukins. During the menopausal period the estrogens’ protective activity is decreased and the production of IL1β and IL6 is increased.The aim of the studyThe assessment of the dependency between IL1β i IL6 and estradiol values and BMD and IBM in postmenopausal women.Material: Forty-eight women, age 49–61, without menstruation ...

Ghrelin is a brain-gut peptide originally identified in the stomach. It binds to and stimulates the growth hormone secretagogue receptor type 1a (GHS-R). The presence of ghrelin in hypothalamic tissue was studied. It has been previously established that neither the synthetic GHSs, nor the endogenous hormone ghrelin, is specific for GH stimulation: they generally also stimulate the HPA axis as well as prolactin release. Since there is no direct stimulatory effect on ACTH releas...

Aims: To evaluate the effect of Liraglutide on clinical parameters in obese Type 2 diabetic patients with inadequate glycemic control despite treatment with oral hypoglycaemic agents (OHAs) and insulin.Methods: Three hundred and fifty three (M:232, F:121) obese (according to Asian-Indian criteria) type 2 diabetic patients with inadequate glycemic control (HbA1c>7% & <10%) attending outpatients clinic on insulin and OHAs were initiated on lira...

The effects of N-terminal parathyroid hormone (PTH) and parathyroid hormone related peptides (PTHrP) on the spontaneous contractility of 4 days pregnant mouse uterus in vitro were investigated. The myometrial tissue contracted vigorously for several hours, when incubated in organ baths in De Jalon's solution. PTH(1-34) and PTHrP(1-40) caused similar dose related inhibitions of contractions over a dose range of 10-9 to 10-7 M. C terminal PTHrP(107-139) was devoid of this...

Introduction: VPA, antiepileptic drug, may cause a number of side effects including reproductive deficits in humans. Previously we found that VPA (1 μM) may suppress GnRH-stimulated release of LH from rat anterior pituitary cells in vitro without affecting its basal secretion (Neuroendocrinol Lett 2011 32 101–106). However mechanism of VPA suppressive activity is still unknown. Since pharmacological effects of VPA require GnRH-R activation, the m...

The blood-brain barrier for peptide hormones is protective for the maternal brain.OBJECTIVE: To compare peptide hormone levels on the two sides of the blood cerebrospinal fluid barrier in pregnant, non pregnant and menopausal women.METHODS: We investigated, with the approval of the local ethics committee, 35 healthy pregnant women at term, aged 21-41 years (group G), 27 non-pregnant women aged 21-43 years (group C) and 15 menopausa...

Introduction: In vitro skeletal muscle cell models are vitally important for investigating the molecular mechanisms of skeletal muscle in metabolic and endocrine diseases, such as obesity and type 2 diabetes. Culture media for skeletal muscle cells can often contain glucose concentrations (GC) five times higher than what’s considered normal in fasting human plasma, thus is not representative of the in vivo environment. Hyperglycaemia in culture media may...

Non-healing foot ulcers are a major complication in diabetic patients. Mesenchymal stem cells (MSCs) are known to promote angiogenesis with improved wound healing. Orbsen Therapeutics has identified a novel antibody (CD362+) which can be used to prospectively FACS-isolate CD362+CD45− MSC from human bone marrow with enhanced MSC/MNC purity ratios of up to 1/4. Excellagen matrix was used to seed the cells as biomaterials are well reported t...